Ludwig A M, Bendfeldt F, Wikler A, Cain R B
Dis Nerv Syst. 1977 Jun;38(6):405-8.
In an appropriate experimental paradigm, loss-of-control drinking can be demonstrated when an individual consumes sufficient ethanol over time to cause his blood alcohol level (BAL) to rise progressively above a previously established, designated range. For this study, 10 alcoholics were exposed to a training session and provided accurate feedback of their blood alcohol level at ten 15-minute intervals. On following days, they were then exposed to three exposed to three experimental sessions during which they were instructed to maintain their BAL within the established training session range by relying primarily on interoceptive cues. The experimental sessions were characterized by distorted or no feedback concerning blood alcohol levels as the basis for drinking-decision behavior. The results indicated that 60% of alcoholics displayed loss-of-control (LOC) (by our criterion) in a least one session, the greatest percentage in the "No Feedback" session. The results were interpreted to support our theory of a neurophysiologic feedback dysfunction associated with LOC drinking.
在适当的实验范式中，当个体随着时间的推移摄入足够的乙醇，导致其血液酒精浓度（BAL）逐渐上升至先前确定的指定范围之上时，就可以证明失控饮酒的存在。在本研究中，10名酗酒者参加了一次培训课程，并每隔15分钟得到一次关于他们血液酒精浓度的准确反馈。在接下来的日子里，他们接受了三次实验，在此期间，他们被要求主要依靠内感受线索将BAL维持在既定的培训范围内。实验的特点是，关于血液酒精浓度的反馈被扭曲或没有反馈，以此作为饮酒决策行为的依据。结果表明，60%的酗酒者在至少一次实验中表现出失控（根据我们的标准），在“无反馈”实验中这一比例最高。这些结果被解释为支持我们关于与失控饮酒相关的神经生理反馈功能障碍的理论。
