Macková N, Praslicka M
Neoplasma. 1981;28(1):79-86.
In this paper the morphological changes in mouse bone marrow till day 60 after the termination of continuous irradiation with the dose rate 4.8 Gy/day (480 rad/day) and the total accumulated doses 9.6 Gy (960 rad) and 19.2 Gy (1920 rad) are evaluated. Many mononuclear cells of the morphologically lymphoid type appear in the bone marrow on day 9 of the recovery and later on extensive granulopoiesis recovery occurs reaching the control level, as early as on day 21--28 after the irradiation. The recovery of erythropoiesis and megakaryocytopoiesis proceeds more slowly and their total recovery occurs within the period of 28--60 days after the irradiation. The total accumulated dose 19.2 Gy (1920 rad) causes irreversible damage in the bone marrow and the death of all experimental animals occurs within 11 days after irradiation.
本文评估了在以4.8 Gy/天（480 rad/天）的剂量率持续照射结束后至第60天小鼠骨髓的形态学变化，以及总累积剂量9.6 Gy（960 rad）和19.2 Gy（1920 rad）的情况。在恢复的第9天，骨髓中出现许多形态上为淋巴样类型的单核细胞，随后在照射后最早于第21 - 28天发生广泛的粒细胞生成恢复并达到对照水平。红细胞生成和巨核细胞生成的恢复进展较为缓慢，它们的完全恢复发生在照射后的28 - 60天内。总累积剂量19.2 Gy（1920 rad）会对骨髓造成不可逆损伤，所有实验动物在照射后11天内死亡。
