Cavanagh J B, Gysbers M F
Neuropathol Appl Neurobiol. 1981 Jul-Aug;7(4):315-26. doi: 10.1111/j.1365-2990.1981.tb00103.x.
The ultrastructural features of the ascending degeneration produced by acrylamide in peripheral nerves above the point of nerve ligature have been described. Before the onset of signs of axonal degeneration abundant accumulation of smooth endoplasmic reticulum and vesicles occur particularly proximal to nodes of Ranvier, but also in internodal regions. Some mitochondrial accumulations occur distal to nodes of Ranvier. The changes closely resemble those found in axons up to 4 mm above a nerve crush in normal animals and appear to be essentially non-specific in nature. Their significance in relation to the subsequent axonal degeneration can only be guessed at.
已描述了丙烯酰胺在神经结扎点上方的周围神经中引起的上行性变性的超微结构特征。在轴突变性迹象出现之前，滑面内质网和小泡大量积聚，尤其在郎飞结近端，但也见于结间区域。在郎飞结远端有一些线粒体积聚。这些变化与正常动物神经挤压上方4毫米以内的轴突中发现的变化非常相似，而且本质上似乎是非特异性的。它们与随后轴突变性的关系只能猜测。
