Huggins G R
Obstet Gynecol. 1981 Oct;58(4):409-16.
The Women's Health Study, a concurrent case-control study at 16 hospitals in 9 cities across the United States, examined the relationship between intrauterine contraceptive device (IUD) use and unexplained vaginal bleeding severe enough to require hospitalization. There were 545 eligible cases and 3453 controls. Analysis of all patients showed no association between IUD use and hospitalization for unexplained vaginal bleeding. When cases were analyzed separately with regard to prior episodes of vaginal bleeding, those patients with a history of vaginal bleeding had a decreased risk of hospitalization. Among cases, no significant differences between IUD users and nonusers were found in rates of anesthesia, blood transfusion, dilatation and curettage, or hysterectomy. The significant decreased risk between current IUD use (within 3 months before the study) and hospitalization for unexplained vaginal bleeding among women with a history of vaginal bleeding may reflect selective nonprescription for IUDs related to past episodes of vaginal bleeding.
妇女健康研究是一项在美国9个城市的16家医院同时开展的病例对照研究，该研究调查了宫内节育器（IUD）的使用与严重到需要住院治疗的不明原因阴道出血之间的关系。共有545例符合条件的病例和3453名对照。对所有患者的分析表明，IUD的使用与因不明原因阴道出血而住院之间没有关联。当根据既往阴道出血发作情况对病例进行单独分析时，那些有阴道出血史的患者住院风险降低。在病例中，IUD使用者和非使用者在麻醉、输血、刮宫或子宫切除术的发生率方面没有发现显著差异。在有阴道出血史的女性中，当前使用IUD（在研究前3个月内）与因不明原因阴道出血而住院之间风险显著降低，这可能反映了与过去阴道出血发作相关的IUD选择性不处方情况。
