Ogburn P L, Cefalo R C, Nagel T, Okagaki T
Obstet Gynecol. 1981 Oct;58(4):513-5.
Histiocytosis X is associated with a pathologic proliferation of mononuclear histiocytes in the reticular endothelial system. Different clinical manifestations of this group of disorders may occur. Pregnancy and histiocytosis X infrequently occur simultaneously. Four cases previously reported along with 1 new case of histiocytosis X and pregnancy are reviewed in this report. Only chronic histiocytosis X, Hand-Schüller-Christian disease (HSCD), has been reported to occur during pregnancy. The most frequent complication during pregnancy was the onset or exacerbation of diabetes insipidus, as frequently seen with this disorder. The possibility that HSCD may alter pituitary function may contribute to the infrequent occurrence of pregnancy in patients with this disorder.
组织细胞增多症X与网状内皮系统中单核组织细胞的病理性增殖有关。这组疾病可能会出现不同的临床表现。妊娠与组织细胞增多症X很少同时发生。本报告回顾了先前报道的4例以及1例新的组织细胞增多症X合并妊娠的病例。据报道，只有慢性组织细胞增多症X，即汉-许-克病（HSCD），会在妊娠期间发生。妊娠期间最常见的并发症是尿崩症的发作或加重，这在该疾病中很常见。HSCD可能改变垂体功能的可能性可能导致该疾病患者妊娠发生率较低。
