Lösel E, Hoffmann G
Nuklearmedizin. 1981 Aug;20(4):169-73.
The global volume alterations of the heart can be estimated non-invasively by means of the "radiocardiographic function analysis" developed by Hoffmann and Kleine. Since the failing heart with its functional disturbances demonstrates a pathological volume behavior under physical exercise, it is possible to use these characteristic to differentiate between the intact heart and the failing heart by registration of the global volume alterations. The "gated blood pool technique" combined with the registration of the intraventricular pressure pulse by means of a Swan-Ganz flow-directed catheter enables demonstration of ventricular stroke work as a pressure-volume loop (work diagram). Its shape indicates whether the ventricle has to perform mainly pressure work or volume work. Myocardial failure is altering the basic conditions of the heart. The work diagram of the failing heart is significantly different from that of the intact human heart. It is shifted in its pressure-volume coordinates according to an increase of EDV and ESV and the rise of the filling pressure. Case demonstrations reveal the global volume behaviour of the heart under varying conditions: resting and physical exercise, drug influence on the intact and failing heart.
心脏的整体容积变化可通过霍夫曼和克莱内开发的“放射心脏造影功能分析”进行无创估计。由于功能失调的衰竭心脏在体育锻炼时表现出病理性的容积行为，因此通过记录整体容积变化，利用这些特征来区分正常心脏和衰竭心脏是可行的。“门控血池技术”与通过Swan-Ganz血流导向导管记录心室内压力脉冲相结合，能够将心室搏功显示为压力-容积环（功图）。其形状表明心室主要进行压力功还是容积功。心肌衰竭正在改变心脏的基本状况。衰竭心脏的功图与正常人心脏的功图显著不同。根据舒张末期容积（EDV）和收缩末期容积（ESV）的增加以及充盈压的升高，其在压力-容积坐标中发生了偏移。病例展示揭示了心脏在不同条件下的整体容积行为：静息和体育锻炼、药物对正常和衰竭心脏的影响。
