Atkins H L, Som P
J Nucl Med. 1979 Jun;20(6):543-6.
The imaging of the pancreas with [75Se]selenomethionine has a low rate of reliability. This study was carried out in order to elucidate some factors that may be important in affecting the degree of uptake of the tracer by the pancreas. Studies were carried out in animals to observe the effects of growth-hormone (GH), somotostatin (SRIF), L-DOPA, and apomorphine administration on the distribution of [75Se]selenomethionine. Intravenously administered GH significantly depressed pancreatic uptake of Se-75 in mice and dogs and depressed the pancreas-to-liver concentration ratio (P/L). The effect of i.p. GH in mice was to decrease the P/L ratio, but the decrease in pancreatic uptake was not statistically significant. There was also a greater effect of GH in dogs than in mice, with pancreatic uptake decreasing from 5.60 +/- 2.17% to 1.24 +/- 0.96% and the P/L from 4.78 +/- 1.85 to 0.97 +/- 0.73. L-DOPA and apomorphine produced effects similar to GH in mice. SRIF in small doses had little effect, but in larger doses it enhanced pancreatic uptake, although not affecting P/L. The results indicate that hypothalamic factors may be important in affecting the function of the exocrine pancreas. Both L-DOPA and apomorphine are known to stimulate GH production through hypothalamic-pituitary pathways. In addition to suppressing GH release, SRIF may have direct effects on the exocrine pancreas.
用[75Se]硒代蛋氨酸对胰腺进行成像的可靠性较低。进行这项研究是为了阐明一些可能对示踪剂在胰腺中的摄取程度有重要影响的因素。在动物身上进行研究，以观察生长激素（GH）、生长抑素（SRIF）、左旋多巴和阿扑吗啡给药对[75Se]硒代蛋氨酸分布的影响。静脉注射生长激素可显著降低小鼠和狗胰腺对硒-75的摄取，并降低胰腺与肝脏的浓度比（P/L）。腹腔注射生长激素对小鼠的作用是降低P/L比值，但胰腺摄取量的降低无统计学意义。生长激素对狗的影响也比对小鼠的影响更大，胰腺摄取量从5.60±2.17%降至1.24±0.96%，P/L从4.78±1.85降至0.97±0.73。左旋多巴和阿扑吗啡在小鼠身上产生的作用与生长激素相似。小剂量的生长抑素作用不大，但大剂量时可增强胰腺摄取，尽管不影响P/L。结果表明，下丘脑因素可能对胰腺外分泌功能有重要影响。已知左旋多巴和阿扑吗啡都通过下丘脑-垂体途径刺激生长激素的产生。除了抑制生长激素释放外，生长抑素可能对胰腺外分泌有直接作用。
