Kitaura K, Araki Y, Marumo H
Jpn J Antibiot. 1980 Jul;33(7):728-32.
Acute toxicity of nanaomycin A was tested in mice and rats. It was found that the antibiotic was well absorbed topically so that topical LD50 was approximately the same as intravenous LD50 in mice. The therapeutic effect of nanaomycin A and siccanin against experimental cutaneous Trichophyton mentagrophytes infection in guinea pigs was investigated. Topically applied formulation of nanaomycin A was very effective in improving the condition of lesions and in preventing fungal growth in the infected tissues. Nanaomycin A and siccanin were comparable in activity in experiments.
对小鼠和大鼠进行了纳那霉素A的急性毒性测试。发现该抗生素经局部给药吸收良好，因此在小鼠中局部LD50与静脉注射LD50大致相同。研究了纳那霉素A和西卡宁对豚鼠实验性皮肤须癣毛癣菌感染的治疗效果。局部应用的纳那霉素A制剂在改善病变状况和预防感染组织中的真菌生长方面非常有效。在实验中，纳那霉素A和西卡宁的活性相当。
