Londong W, Londong V, Hanssen L E, Schwanner A
Regul Pept. 1981 Aug;2(4):231-44. doi: 10.1016/0167-0115(81)90027-6.
The gastric effects of synthetic secretin given in a depot preparation as subcutaneous injection or in different doses as intravenous infusion were studied in 10 healthy volunteers. Peptone-stimulated gastric acid secretion and serum gastrin were significantly suppressed with a clear dose-response inhibition of acid output. There was a significant correlation between percentage inhibition of acid secretion and plasma secretin concentrations which were greatly above those seen physiologically. Serum lipase and trypsin increased significantly. Most subjects lost fluid from diuresis and diarrhoea, so that serum sodium and total protein concentrations also increased significantly. These side effects cast doubt on the clinical value of prolonged infusions of pharmacological doses of synthetic secretion in critically ill patients.
在10名健康志愿者中研究了以长效制剂皮下注射或不同剂量静脉输注合成促胰液素的胃效应。蛋白胨刺激的胃酸分泌和血清胃泌素受到显著抑制，酸分泌呈现明显的剂量反应性抑制。酸分泌抑制百分比与血浆促胰液素浓度之间存在显著相关性，血浆促胰液素浓度大大高于生理水平。血清脂肪酶和胰蛋白酶显著增加。大多数受试者因利尿和腹泻而体液流失，因此血清钠和总蛋白浓度也显著增加。这些副作用使人对在重症患者中长时间输注药理剂量的合成促胰液素的临床价值产生怀疑。
