Londong W, Londong V, Mühlbauer R, König A
Medizinische Klinik Innenstadt, University of Munich, FRG.
Scand J Gastroenterol Suppl. 1987;139:25-31. doi: 10.3109/00365528709089771.
In this randomized, double-blind, placebo-controlled study therapeutic doses of synthetic secretin (0.5 CU/kg/h) and somatostatin (3.5 micrograms/kg/h) given an intravenous infusion suppressed significantly peptone-stimulated gastric acid output per 3 h in nine male healthy subjects from 59.2 +/- 7.4 mmol H+ (placebo) to 16.9 +/- 3.1 and 6.6 +/- 1.5 mmol H+, respectively. Peptone-stimulated gastrin release was reduced to basal concentrations by both hormones. In five subjects secretin raised serum lipase to pathological concentrations. Somatostatin diminished significantly mean blood glucose concentrations. Both had opposite renal effects; secretin showed diuretic and somatostatin antidiuretic properties. Secretin and somatostatin were well tolerated. It is concluded from these data that therapeutic doses of secretin and somatostatin are comparably effective on exocrine and endocrine gastric functions, but have opposite effects on renal functions in man.
在这项随机、双盲、安慰剂对照研究中，对9名健康男性受试者静脉输注治疗剂量的合成促胰液素（0.5 CU/kg/h）和生长抑素（3.5微克/千克/小时），显著抑制了蛋白胨刺激的每3小时胃酸分泌量，从59.2±7.4毫摩尔H⁺（安慰剂组）分别降至16.9±3.1和6.6±1.5毫摩尔H⁺。两种激素均使蛋白胨刺激的胃泌素释放降至基础浓度。在5名受试者中，促胰液素使血清脂肪酶升高至病理浓度。生长抑素显著降低了平均血糖浓度。两者对肾脏有相反的作用；促胰液素显示出利尿特性，而生长抑素显示出抗利尿特性。促胰液素和生长抑素耐受性良好。从这些数据得出结论，治疗剂量的促胰液素和生长抑素对外分泌和内分泌胃功能的作用相当，但对人体肾脏功能有相反的影响。
