Susić D, Haxhiu M, Kentera D
Respiration. 1981;41(3):166-73. doi: 10.1159/000194374.
The pulmonary vascular response to an acute hypoxic stimulus was examined in rats which were kept for 4 weeks in a hypoxic environment and compared to that of rats kept in a normoxic environment. To this end, the effects of breathing gas mixtures containing 7, 21 an 100% O2 on right ventricular systolic pressure (RVPs), cardiac output (Q) and calculated pulmonary vascular resistance (PVR) in chronically hypoxic (CH) rats and rats kept in a normoxic environment (N) were examined. During breathing of 21% O2 RVPs, Q, and PVR were all higher in CH than in N rats. Breathing a gas mixture containing 7% O2 had no effect on systemic blood pressure, heart rate or Q, in both CH and N rats. When compared to breathing of 21% O2, the RVP and PVR remained unchanged in CH rats breathing 7% O2, while both variables significantly (p less than 0.01) increased in N rats. The presented data indicate that the reaction of the pulmonary vasculature to an hypoxic challenge is decreased in CH rats.
在低氧环境中饲养4周的大鼠中检测了肺血管对急性低氧刺激的反应，并与饲养在常氧环境中的大鼠进行了比较。为此，研究了呼吸含7%、21%和100%氧气的混合气体对慢性低氧（CH）大鼠和常氧环境（N）大鼠右心室收缩压（RVPs）、心输出量（Q）和计算得出的肺血管阻力（PVR）的影响。在呼吸21%氧气时，CH大鼠的RVPs、Q和PVR均高于N大鼠。呼吸含7%氧气的混合气体对CH大鼠和N大鼠的全身血压、心率或Q均无影响。与呼吸21%氧气相比，CH大鼠呼吸7%氧气时RVP和PVR保持不变，而N大鼠的这两个变量均显著（p<0.01）增加。所呈现的数据表明，CH大鼠肺血管系统对低氧刺激的反应降低。
