Kentera D, Susić D, Zdravković M
Basic Res Cardiol. 1985 Mar-Apr;80(2):142-6. doi: 10.1007/BF01910461.
Daily heparin injections (300 mg s.c.) during four weeks of hypoxic exposure resulted in a smaller rise in pulmonary artery pressure as compared with otherwise nontreated rats exposed to the same regimen of hypoxia. Heparin treatment did not significantly affect the systemic arterial pressure of the hypoxic rats. In spite of the different pressure load of the right ventricle after hypoxia in treated and control rats, there was no difference in parameters indicative of the degree of right ventricular hypertrophy between these two groups of hypoxic rats. This finding suggests that the difference in pressure load between the two groups of hypoxic rats occurred late in the course of hypoxic exposure.
在四周的低氧暴露期间每日皮下注射肝素（300毫克），与暴露于相同低氧方案但未接受其他治疗的大鼠相比，肺动脉压的升高幅度较小。肝素治疗对低氧大鼠的体动脉压没有显著影响。尽管治疗组和对照组大鼠在低氧后右心室的压力负荷不同，但这两组低氧大鼠之间在提示右心室肥厚程度的参数方面没有差异。这一发现表明，两组低氧大鼠之间的压力负荷差异出现在低氧暴露过程的后期。
