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胰岛素在泌乳大鼠乳腺脂肪生成调节中作用的证据。饥饿和再喂养后体内脂肪生成及血浆激素浓度的测定。

Evidence for a role of insulin in the regulation of lipogenesis in lactating rat mammary gland. Measurements of lipogenesis in vivo and plasma hormone concentrations in response to starvation and refeeding.

作者信息

Robinson A M, Girard J R, Williamson D H

出版信息

Biochem J. 1978 Oct 15;176(1):343-6. doi: 10.1042/bj1760343.

DOI:10.1042/bj1760343
PMID:728115
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1186235/
Abstract

Fatty acid synthesis in the mammary gland of lactating rats in vivo was 5-fold higher than in the liver. Starvation decreased fatty acid synthesis in the gland 50-fold, whereas refeeding for 2h completely reversed this change. The plasma insulin concentration decreased 2-fold in starvation and was restored to the fed-rat value on refeeding. Glucagon and prolactin concentrations did not always change in parallel with lipogenesis, suggesting that insulin may be a regulator of this process in the gland.

摘要

哺乳期大鼠乳腺中脂肪酸的合成在体内比肝脏中高5倍。饥饿使乳腺中脂肪酸的合成降低了50倍，而重新喂食2小时则完全逆转了这一变化。饥饿时血浆胰岛素浓度降低了2倍，重新喂食后恢复到喂食大鼠的水平。胰高血糖素和催乳素的浓度并不总是与脂肪生成平行变化，这表明胰岛素可能是该腺体中这一过程的调节因子。

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1
Evidence for a role of insulin in the regulation of lipogenesis in lactating rat mammary gland. Measurements of lipogenesis in vivo and plasma hormone concentrations in response to starvation and refeeding.胰岛素在泌乳大鼠乳腺脂肪生成调节中作用的证据。饥饿和再喂养后体内脂肪生成及血浆激素浓度的测定。
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2
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本文引用的文献

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Enzymic determination of D(-)-beta-hydroxybutyric acid and acetoacetic acid in blood.血液中D(-)-β-羟基丁酸和乙酰乙酸的酶法测定
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Glucagon and the insulin: glucagon ratio in diabetes and other catabolic illnesses.糖尿病及其他分解代谢性疾病中胰高血糖素与胰岛素：胰高血糖素比值
Diabetes. 1971 Dec;20(12):834-8. doi: 10.2337/diab.20.12.834.
7
A sensitive, precise radioimmunoassay of serum insulin relying on charcoal separation of bound and free hormone moieties.一种依靠结合型和游离型激素部分的活性炭分离技术的灵敏、精确的血清胰岛素放射免疫测定法。
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Glucagon secretion during the early postnatal period in the rat.大鼠出生后早期的胰高血糖素分泌
Horm Metab Res. 1972 May;4(3):168-70. doi: 10.1055/s-0028-1094093.
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The effects of pregnancy, lactation and involution on the metabolism of glucose by rat parametrial adipose tissue.妊娠、泌乳和 involution 对大鼠子宫旁脂肪组织葡萄糖代谢的影响。 （注：这里“involution”可能是专业术语“ involution”，意为退化、复旧等，在医学文献中具体含义需结合上下文确定。）
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Changes in concentration of prolactin and adrenal corticosteroids in rat plasma during pregnancy and lactation.大鼠妊娠和哺乳期血浆中催乳素和肾上腺皮质类固醇浓度的变化。
J Endocrinol. 1973 Sep;58(3):675-6. doi: 10.1677/joe.0.0580675.