胰岛素在泌乳大鼠乳腺脂肪生成调节中作用的证据。饥饿和再喂养后体内脂肪生成及血浆激素浓度的测定。
Evidence for a role of insulin in the regulation of lipogenesis in lactating rat mammary gland. Measurements of lipogenesis in vivo and plasma hormone concentrations in response to starvation and refeeding.
作者信息
Robinson A M, Girard J R, Williamson D H
出版信息
Biochem J. 1978 Oct 15;176(1):343-6. doi: 10.1042/bj1760343.
Abstract
Fatty acid synthesis in the mammary gland of lactating rats in vivo was 5-fold higher than in the liver. Starvation decreased fatty acid synthesis in the gland 50-fold, whereas refeeding for 2h completely reversed this change. The plasma insulin concentration decreased 2-fold in starvation and was restored to the fed-rat value on refeeding. Glucagon and prolactin concentrations did not always change in parallel with lipogenesis, suggesting that insulin may be a regulator of this process in the gland.
摘要
哺乳期大鼠乳腺中脂肪酸的合成在体内比肝脏中高5倍。饥饿使乳腺中脂肪酸的合成降低了50倍，而重新喂食2小时则完全逆转了这一变化。饥饿时血浆胰岛素浓度降低了2倍，重新喂食后恢复到喂食大鼠的水平。胰高血糖素和催乳素的浓度并不总是与脂肪生成平行变化，这表明胰岛素可能是该腺体中这一过程的调节因子。
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