饥饿的清醒泌乳大鼠重新进食期间血浆葡萄糖和胰岛素浓度以及乳腺脂肪生成变化的时间进程。
Time course of changes in plasma glucose and insulin concentrations and mammary-gland lipogenesis during re-feeding of starved conscious lactating rats.
作者信息
Mercer S W, Williamson D H
出版信息
Biochem J. 1986 Oct 15;239(2):489-92. doi: 10.1042/bj2390489.
Abstract
Temporal changes in circulating insulin concentrations were measured during re-feeding of 18 h-starved lactating rats. Insulin concentrations rose rapidly over the first 20 min of re-feeding with 5 g of chow diet, and then sharply declined between 20-30 min and remained low for the rest of the 90 min experimental period. Lipogenic activity in the mammary gland also exhibited a peak during re-feeding, but there was a clear time lag between the insulin response and the lipogenic response. Blood-flow measurements failed to show any major increase to the tissue during this activation of lipogenesis. Acute suppression of insulin secretion at 30 min (after the initial surge) abolished the switch-on of lipogenesis, suggesting that the insulin-sensitivity of the gland may be acutely enhanced over this period of re-feeding.
摘要
在对禁食18小时的泌乳大鼠重新喂食期间，测量了循环胰岛素浓度的时间变化。用5克饲料重新喂食的最初20分钟内，胰岛素浓度迅速上升，然后在20 - 30分钟之间急剧下降，并在90分钟实验期的剩余时间内保持在低水平。乳腺中的脂肪生成活性在重新喂食期间也出现了一个峰值，但胰岛素反应和脂肪生成反应之间存在明显的时间滞后。在脂肪生成激活期间，血流量测量未能显示该组织有任何显著增加。在30分钟时（最初激增后）急性抑制胰岛素分泌消除了脂肪生成的开启，这表明在重新喂食期间，乳腺的胰岛素敏感性可能会急剧增强。
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