Heinroth I, Förster W
Acta Biol Med Ger. 1980;39(8-9):961-6.
The influence of reserpine, alpha-methyldopa and clonidine on the activity of lipoprotein lipase (LPL) of the rabbit heart and the effect of reserpine on the LPL activity of the cardiac tissue of normotonic and spontaneously hypertensive rats was investigated by a modified method of Robinson, Reserpine and alpha-methyldopa caused in the rabbit heart muscle a pronounced increase in LPL activity by 74 and 35%, respectively. Stimulation by clonidine was not statistically verified. Application of reserpine increases the LPL activity in the hearts both of normotonic and spontaneously hypertensive rats. The enzyme activity in the hypertrophied hearts of spontaneously hypertensive rats is not enhanced. The results are discussed in connection with changes of the catecholamine level.
采用改良的罗宾逊方法，研究了利血平、α-甲基多巴和可乐定对兔心脏脂蛋白脂肪酶（LPL）活性的影响，以及利血平对正常血压和自发性高血压大鼠心脏组织LPL活性的影响。利血平和α-甲基多巴使兔心肌中的LPL活性分别显著增加了74%和35%。可乐定的刺激作用未得到统计学验证。利血平的应用增加了正常血压和自发性高血压大鼠心脏中的LPL活性。自发性高血压大鼠肥厚心脏中的酶活性未增强。结合儿茶酚胺水平的变化对结果进行了讨论。
