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下丘脑腹内侧核电刺激及6-羟基多巴胺对家兔心脏脂蛋白脂肪酶活性的影响

Effect of hypothalamic ventro-medial nucleus electric stimulation and 6-hydroxydopamine on cardiac lipoprotein lipase activity in rabbits.

作者信息

Lavín-Palmieri M, Cabrera-Santos A, García-Pérez M, Sánchez-Serrano D, Nieto-Lluis C

出版信息

Cor Vasa. 1983;25(1):73-7.

PMID:6406142
Abstract

The influence of hypothalamic electric stimulation and administration of 6-hydroxydopamine (6-OHDA) on cardiac lipoprotein lipase (LPL) activity was investigated in 19 rabbits either acutely stimulated in the hypothalamic ventro-medial nucleus (HVMN), or injected with 6-OHDA, or submitted to both experimental procedures. 6 animals served as controls. In rabbits pretreated with 6-OHDA a significant decrease of LPL activity was found with respect to controls (p less than 0.005) and also to stimulated animals (p less than 0.005). The possible mechanism underlying this change is discussed.

摘要

研究了下丘脑电刺激和给予6-羟基多巴胺(6-OHDA)对19只家兔心脏脂蛋白脂肪酶(LPL)活性的影响。这些家兔分别接受下丘脑腹内侧核(HVMN)急性刺激、注射6-OHDA或两种实验操作。6只动物作为对照。在预先用6-OHDA处理的家兔中,发现LPL活性相对于对照组(p<0.005)以及刺激组动物(p<0.005)均显著降低。讨论了这种变化潜在的可能机制。

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