Søreide A J
Acta Anat (Basel). 1981;110(1):40-7.
The retrograde nerve cell reaction was studied after crush lesion of the facial nerve in rats of different ages. Neuronal survival increased from 10% in newborn rats to 100% in adults. In 8- or 10-day-old animals axotomy caused central chromatolysis. nuclear eccentricity, folding of the nuclear membrane, and development of nuclear caps. Similar lesions in adult rats caused only minimal changes. In findings differ from those previously reported in hamsters (la Velle and La Velle, 1958a, b, 1959], where chromatolysis was most severe in adult animals. However, the neuronal survival followed the same age-related pattern in rats and hamsters. Thus, there are marked species differences in chromatolytic response after axotomy, but these decisive factor for neuronal recovery after axon injury in young animals.
在不同年龄的大鼠面神经挤压损伤后，对逆行性神经细胞反应进行了研究。神经元存活率从新生大鼠的10%增加到成年大鼠的100%。在8日龄或10日龄动物中，轴突切断导致中央性染色质溶解、核偏心、核膜折叠和核帽形成。成年大鼠的类似损伤仅引起微小变化。这些发现与先前在仓鼠中报道的结果不同（拉韦勒和拉韦勒，1958a、b，1959），在仓鼠中成年动物的染色质溶解最为严重。然而，大鼠和仓鼠的神经元存活率遵循相同的年龄相关模式。因此，轴突切断后染色质溶解反应存在明显的物种差异，但这些差异并不是幼龄动物轴突损伤后神经元恢复的决定性因素。
