Szabó G, Pósch E, Magyar Z
Acta Physiol Acad Sci Hung. 1980;56(4):367-78.
Venous and interstitial fluid pressure, protein content of blood plasma, leg lymph and interstitial fluid were estimated in anaesthetized normal dogs and rabbits as well as in dogs with chronic inferior v. cava constriction. In the tissue fluid collected by the perforated capsule and by the wick methods protein concentrations were the same. In the rabbit hindlegs subcutaneous tissue fluid and lymph protein concentrations were 50 and 45%, respectively of plasma protein concentration. In the dog tissue fluid, protein was 42.5% but lymph protein content was only 17% of plasma protein. Tissue fluid hydraulic pressure (intracapsular) was in normal dogs--5.0 +/- 1.3 mm Hg and it increased in cava constricted dogs to +0.8 +/- 0.4 mm Hg. In caval constriction, protein concentration in the interstitial fluid decreased markedly. A linear relationship was found in dogs and rabbits between tissue fluid and lymph protein concentration (r = 0.68 and 0.73, respectively). The relationship between venous and tissue fluid (intracapsular) pressures was non-linear. In dog hindlimbs the calculated isogravimetric capillary pressure was 7.8 mm Hg. In venous congestion both the increase of interstitial fluid hydraulic pressure, and the decrease of oncotic pressure ace as "oedema safety factors". In the rabbit 20 h after the intravenous injection of labelled albumin there was no significant difference between the specific radioactive albumin contents of plasma, leg lymph and tissue fluid.
在麻醉的正常犬和兔以及慢性下腔静脉狭窄的犬中，对静脉和组织间液压力、血浆、腿部淋巴液和组织间液的蛋白质含量进行了评估。通过穿孔胶囊法和灯芯法收集的组织液中蛋白质浓度相同。在兔后肢，皮下组织液和淋巴液中的蛋白质浓度分别为血浆蛋白质浓度的50%和45%。在犬的组织液中，蛋白质含量为42.5%，但淋巴液中的蛋白质含量仅为血浆蛋白质的17%。正常犬的组织液液压（囊内）为-5.0±1.3 mmHg，在下腔静脉狭窄的犬中增加到+0.8±0.4 mmHg。在下腔静脉狭窄时，组织间液中的蛋白质浓度明显降低。在犬和兔中发现组织液和淋巴液蛋白质浓度之间存在线性关系（r分别为0.68和0.73）。静脉和组织液（囊内）压力之间的关系是非线性的。在犬后肢，计算出的等重力毛细血管压力为7.8 mmHg。在静脉淤血时，组织间液液压的增加和胶体渗透压的降低均作为“水肿安全因素”。在兔静脉注射标记白蛋白20小时后，血浆、腿部淋巴液和组织间液中特异性放射性白蛋白含量之间无显著差异。
