Pettersen E O, Lindmo T
Acta Radiol Oncol Radiat Phys Biol. 1978;17(4):319-30. doi: 10.3109/02841867809127935.
Cell cycle kinetics and radiation response under hypoxic conditions were analyzed with human cells of the line NHIK 3025. The cells were either kept in continuous exponential growth by frequent reculturing, or went through log and plateau phase for each passage (recultured weekly). The cell cycle time for weekly recultured populations in early log phase was shorter than for cells in continous exponential growth. Cells in continuous exponential growth were more sensitive to radiation than cells in log phase. The difference in sensitivity was not due to partial synchrony of weekly recultured populations.
利用NHIK 3025系人类细胞分析了缺氧条件下的细胞周期动力学和辐射反应。这些细胞要么通过频繁传代保持持续指数生长，要么每传代一次（每周传代）经历对数期和平稳期。处于对数期早期的每周传代群体的细胞周期时间比持续指数生长的细胞短。持续指数生长的细胞比对数期的细胞对辐射更敏感。敏感性的差异并非由于每周传代群体的部分同步性。
