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Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy.肿瘤球体作为药物输送和疗效测试模型的应用机会和挑战。
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Induced pluripotent stem cell-related genes influence biological behavior and 5-fluorouracil sensitivity of colorectal cancer cells.诱导多能干细胞相关基因影响结直肠癌细胞的生物学行为和 5-氟尿嘧啶敏感性。
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本文引用的文献

1
Age-dependent cell inactivation by vincristine alone or in combination with 1-propargyl-5-chloropyrimidin-2-one.长春新碱单独或与1-丙炔基-5-氯嘧啶-2-酮联合使用时的年龄依赖性细胞失活。
Cancer Res. 1980 Jun;40(6):2069-73.
2
A multi-component radiation survival curve using an in vitro tumour model.使用体外肿瘤模型的多成分辐射存活曲线。
Int J Radiat Biol Relat Stud Phys Chem Med. 1970;18(5):491-5. doi: 10.1080/09553007014551401.
3
Effects of intercellular contact on repair of radiation damage.细胞间接触对辐射损伤修复的影响。
Exp Cell Res. 1972 Mar;71(1):75-80. doi: 10.1016/0014-4827(72)90265-0.
4
Adriamycin: a possible indirect radiosensitizer of hypoxic tumor cells.阿霉素：一种可能的缺氧肿瘤细胞间接放射增敏剂。
Radiology. 1976 Apr;119(1):217-22. doi: 10.1148/119.1.217.
5
A comparative study of post-irradiation growth kinetics of spheroids and monolayers.球体和单层细胞辐照后生长动力学的比较研究
Int J Radiat Biol Relat Stud Phys Chem Med. 1975 Sep;28(3):255-65. doi: 10.1080/09553007514551011.
6
A simplified method for production and growth of multicellular tumor spheroids.一种用于多细胞肿瘤球体生产与生长的简化方法。
Cancer Res. 1977 Oct;37(10):3639-43.
7
Kinetic response of an in vitro "tumour-model" (V 79 spheroids) to 42 degrees C hyperthermia.体外“肿瘤模型”（V79球体）对42摄氏度热疗的动力学反应。
Eur J Cancer (1965). 1977 Jan;13(1):23-8. doi: 10.1016/0014-2964(77)90225-0.
8
Effects of different growth conditions on survival after irradiation in hypoxia of human cells (NHIK 3025) in vitro.不同生长条件对人细胞（NHIK 3025）体外低氧照射后存活的影响。
Acta Radiol Oncol Radiat Phys Biol. 1978;17(4):319-30. doi: 10.3109/02841867809127935.
9
Inhibitory effects of the new mitotic inhibitor 5-chloropyrimidin-2-one and of vincristine on human cells in vitro.新型有丝分裂抑制剂5-氯嘧啶-2-酮与长春新碱对人细胞的体外抑制作用。
Cancer Res. 1978 Mar;38(3):560-5.
10
Resistance to adriamycin in multicellular spheroids.多细胞球体对阿霉素的耐药性。
Int J Radiat Oncol Biol Phys. 1979 Aug;5(8):1225-30. doi: 10.1016/0360-3016(79)90643-6.

Resistance to vincristine of human cells grown as multicellular spheroids.

作者信息

Wibe E

出版信息

Br J Cancer. 1980 Dec;42(6):937-41. doi: 10.1038/bjc.1980.344.

DOI:10.1038/bjc.1980.344
PMID:7459228
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2010577/
Abstract
摘要