Smit-Vis J H
Anat Anz. 1981;149(5):455-70.
In a cross-sectional study the postnatal development of the skull, particularly that of the cranial base, was studied in experimentally bipedal male rats, up to the age of 46 weeks. A total of 81 bipedal rats and a control group of 90 animals were studied. It was found that, as compared with control rats, the bipedal rats had a definitely more spherical skull. This was the result of an increased height and a stronger dorsal flexion of the anterior cranial base. As to the chondrocranial elements, the basi-occipital bone reached, on the average, the same length in bipedal rats as in controls. However, the basisphenoid bone was significantly shorter. Arguments are given to relate the latter phenomenon to the altered shape of the neurocranium. The conclusion is drawn that, in this experimental approach, chondrocranial growth at the intersphenoidal synchondrosis is controlled not only by intrinsic genetic factors but also by local epigenetic and/or environmental factors.
在一项横断面研究中，对实验性双足雄性大鼠直至46周龄的颅骨，尤其是颅底的产后发育进行了研究。共研究了81只双足大鼠和一个由90只动物组成的对照组。结果发现，与对照大鼠相比，双足大鼠的颅骨明显更呈球形。这是前颅底高度增加和更强的背侧弯曲的结果。关于软骨颅成分，双足大鼠的枕骨基部平均长度与对照组相同。然而，蝶骨基部明显更短。文中给出了将后一种现象与神经颅骨形状改变相关联的论据。得出的结论是，在这种实验方法中，蝶间软骨结合处的软骨颅生长不仅受内在遗传因素控制，还受局部表观遗传和/或环境因素控制。
