全身麻醉下手术对安替比林清除率的影响。
Effect of surgery under general anaesthesia on antipyrine clearance.
作者信息
Pessayre D, Allemand H, Benoist C, Afifi F, François M, Benhamou J P
出版信息
Br J Clin Pharmacol. 1978 Dec;6(6):505-13. doi: 10.1111/j.1365-2125.1978.tb00874.x.
1 The effect of surgery under general anaesthesia on drug metabolism was investigated in man. The activity of hepatic drug-metabolizing enzymes was evaluated by measurement of antipyrine clearance, before surgery and 3 days after surgery, in eighteen patients. 2 In those patients in whom the operation lasted 2 h or less, the postoperative clearance of antipyrine was significantly (P less than 0.05) increased by 48%; in those patients in whom the operation lasted 2--4 h, it was non-significantly decreased by 36%; in those patients in whom the operation lasted more than 4 h, it was significantly decreased by 47% (P less than 0.01). 3 It is concluded (a) that short operations are followed by increased activity of hepatic drug-metabolizing enzymes, whereas (b) protracted operations are followed by decreased activity. It is suggested (a) that the former effect may be a consequence of enzyme induction by drugs used for premedication and anaesthesia, whereas (b) the latter effect may be the result of major surgical trauma.
1 在人体中研究了全身麻醉下手术对药物代谢的影响。通过测量18名患者术前及术后3天的安替比林清除率，评估肝脏药物代谢酶的活性。2 手术持续时间在2小时及以下的患者，术后安替比林清除率显著（P<0.05）升高48%；手术持续时间在2至4小时的患者，清除率无显著下降，降低了36%；手术持续时间超过4小时的患者，清除率显著下降47%（P<0.01）。3 得出的结论是：（a）短时间手术之后肝脏药物代谢酶活性增加，而（b）长时间手术之后酶活性降低。有人提出：（a）前一种效应可能是术前用药和麻醉所用药物诱导酶的结果，而（b）后一种效应可能是重大手术创伤的结果。
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