新型β-肾上腺素能受体阻断药物喷布洛尔对心肌收缩力的影响。
The effect on myocardial contractility of a new beta-adrenergic receptor blocking drug, penbutolol.
作者信息
Sapru R P, Sharma P L
出版信息
Br J Clin Pharmacol. 1978 Dec;6(6):515-20. doi: 10.1111/j.1365-2125.1978.tb00875.x.
Abstract
1 The inotropic effect of penbutolol, a new beta-adrenergic receptor blocking drug, has been compared with that of propranolol in two similar groups of six subjects each. 2 Inotropic changes were assessed from changes in myocardial contractility index [LV dp-dt/11 T] as well as the slope of the regression line relating LV dp/dt to LVED during incremental pacing. 3 Penbutolol was found to have a significant negative inotropic effect of an order similar to that of propranolol in the respective doses studied.
摘要
- 已在两组各有六名受试者的相似人群中，将新型β-肾上腺素能受体阻断药喷布洛尔的变力作用与普萘洛尔的变力作用进行了比较。2. 根据心肌收缩力指数[左室dp-dt/11T]的变化以及在递增起搏期间左室dp/dt与左室舒张末期内径（LVED）关系回归线的斜率来评估变力变化。3. 发现在所研究的各自剂量下，喷布洛尔具有与普萘洛尔相似程度的显著负性变力作用。
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