单次剂量的喷布洛尔和长效普萘洛尔对精神运动性能的影响。
The effect of single doses of penbutolol and propranolol L.A. on psychomotor performance.
作者信息
Broadhurst A D, Monaghan A T
出版信息
Br J Clin Pharmacol. 1984 May;17(5):591-4. doi: 10.1111/j.1365-2125.1984.tb02396.x.
Abstract
The effect of single oral doses of penbutolol (40 mg) and propranolol L.A. (160 mg) on psychomotor performance of 12 normal individuals has been investigated. Subjects were randomly administered penbutolol, propranolol L.A. and placebo according to a double-blind, three-part cross-over design. At 3 h post-dosing both penbutolol and propranolol L.A. significantly increased (P less than 0.001) complex reaction times when compared to placebo. By 24 h post-dosing the mean complex reaction times for penbutolol and propranolol L.A. were not significantly different from placebo.
摘要
研究了单次口服喷布洛尔（40毫克）和长效普萘洛尔（160毫克）对12名正常个体精神运动表现的影响。受试者按照双盲、三部分交叉设计随机服用喷布洛尔、长效普萘洛尔和安慰剂。给药后3小时，与安慰剂相比，喷布洛尔和长效普萘洛尔均显著增加（P<0.001）复合反应时间。给药后24小时，喷布洛尔和长效普萘洛尔的平均复合反应时间与安慰剂无显著差异。
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