Isupov I V, Nazarova L S, Pavlova L P, Go'kova A V, Podoprigora G I
Arkh Patol. 1981;43(5):36-41.
The effect of purified cholera toxin and the O-antigen of Vibrio cholerae inoculated separately into the intestines of germ-free suckling rabbits on the structure of the viscera and enzymatic changes in them was studied. The purified cholera toxin exerted mostly a local effect on the intestinal tract but caused lesions in the lymphoid tissue. The O-antigen was toxic causing primarily lesions in the liver and kidneys. Crude cholera toxin exerted a complex effect on gnotobiotic rabbits typical of the cholerogen and O-antigen.
研究了将纯化的霍乱毒素和霍乱弧菌O抗原分别接种到无菌乳兔肠道中对其内脏结构及其中酶变化的影响。纯化的霍乱毒素主要对肠道产生局部作用，但会导致淋巴组织损伤。O抗原具有毒性，主要引起肝脏和肾脏损伤。粗制霍乱毒素对悉生兔产生了一种典型的霍乱原和O抗原的复合作用。
