Tonietti G, Caruso L, Ranucci A, Pavan A, Premrov M G
Boll Soc Ital Biol Sper. 1981 Jun 15;57(11):1237-41.
The incidence of anti-myocardial autoantibodies was investigated in 62 patients suffering from congenital or acquired cardiopathy prior to and 1, 10 and 20 days after cardiac surgery. Anti-myocardial autoantibodies were present in about 23.7 per cent of patients even before surgery, practically doubled one day after intervention, reached their peak (60-70 per cent) at 10 days from surgery and began to diminish at 20 days. At all times and incidence was higher in patients with acquired cardiopathy than in those with congenital heart diseases. In the large majority of cases, the autoantibodies were of the IgG class, of the striational type and in low titers. The relevance of anti-myocardial autoantibodies in the pathogenesis of cardiac lesions and the possible causes of the reversibility of the autoimmune phenomenon are discussed.
在62例先天性或后天性心脏病患者心脏手术前、术后1天、10天和20天，对其抗心肌自身抗体的发生率进行了研究。甚至在手术前，约23.7%的患者就存在抗心肌自身抗体，术后1天其发生率几乎翻倍，术后10天达到峰值（60%-70%），术后20天开始下降。在所有时间点，后天性心脏病患者的抗体发生率均高于先天性心脏病患者。在大多数病例中，自身抗体为IgG类、横纹肌型且滴度较低。文中讨论了抗心肌自身抗体在心脏病变发病机制中的相关性以及自身免疫现象可逆性的可能原因。
