芬氟拉明对大鼠摄食和饮水微观结构的影响。
The effect of fenfluramine on the microstructure of feeding and drinking in the rat.
作者信息
Burton M J, Cooper S J, Popplewell D A
出版信息
Br J Pharmacol. 1981 Apr;72(4):621-33. doi: 10.1111/j.1476-5381.1981.tb09142.x.
Abstract
- The effects of three doses of fenfluramine on feeding and drinking in the rat were examined. 2. Feeding and drinking were subdivided into meals and bouts, and the changes in feeding/drinking were expressed in terms of meal/bout frequency, meal/bout size, meal/bout length, and eating/drinking rate. 3. The changes in these parameters were examined over different time periods after the injection. 4. Significant changes in the distribution of inter-response intervals within meals were found in time period 1 with 5 mg/kg and 10 mg/kg doses of fenfluramine. Videotape and computer analysis showed that the changes in inter-response interval histograms differed significantly from those seen in normal animals approaching satiety. Drinking parameters also changed. 5. Compensatory increases in feeding were observed in time period 4 with the 10 mg/kg dose. 6. The difficulties in designing and interpreting experiments in feeding are discussed, and the action of fenfluramine as an anorectic drug is considered.
摘要
- 研究了三种剂量的芬氟拉明对大鼠进食和饮水的影响。2. 进食和饮水被细分为餐次和饮次，进食/饮水的变化用餐次/饮次频率、餐次/饮次量、餐次/饮次时长以及进食/饮水速率来表示。3. 在注射后不同时间段检查这些参数的变化。4. 在第1时间段，5毫克/千克和10毫克/千克剂量的芬氟拉明使餐内反应间隔分布出现显著变化。录像带和计算机分析表明，反应间隔直方图的变化与接近饱腹感的正常动物显著不同。饮水参数也发生了变化。5. 在第4时间段，10毫克/千克剂量组观察到进食的代偿性增加。6. 讨论了设计和解释进食实验的困难，并考虑了芬氟拉明作为一种厌食药物的作用。
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