华法林和维生素K-1对体内凝血酶原羧化和糖基化的影响。
The effect of warfarin and vitamin K-1 on the carboxylation and glycosylation of prothrombin in vivo.
作者信息
Meeks R G, Couri D
出版信息
Biochim Biophys Acta. 1978 Dec 18;544(3):634-7. doi: 10.1016/0304-4165(78)90337-9.
PMID:728474
Abstract
The effect of warfarin and vitamin K-1 on the carboxylation and glycosylation of prothrombin in the rat in vivo was investigated. Neither warfarin nor vitamin K-1 had an effect on carboxylation. However, warfarin inhibited glycosylation 80-90% and this inhibition was readily reversed by the administration of vitamin K-1.
摘要
研究了华法林和维生素K-1对大鼠体内凝血酶原羧化和糖基化的影响。华法林和维生素K-1对羧化均无影响。然而，华法林抑制糖基化80%-90%，且通过给予维生素K-1这种抑制作用可迅速逆转。
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