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人类大肠癌中的早熟染色体凝集

Premature chromosome condensation in human large bowel cancer.

作者信息

Reichmann A, Levin B

出版信息

Cancer Genet Cytogenet. 1981 Apr;3(3):221-5. doi: 10.1016/0165-4608(81)90087-x.

DOI:10.1016/0165-4608(81)90087-x
PMID:7284984
Abstract

Two patients with large bowel cancer are described in whose tumors the presence of cells with premature chromosome condensation (PCC) was encountered. The percentage of PCC In the tumors was 6.9 and 6.6%. We hypothesize that the near tetraploid chromosome number present in the tumor cells in both patients may be the product of fusion of two near diploid malignant cells. Also it is speculated that some colorectal tumors with chromosomes ranging from the hypotriploid to the hypotetraploid levels may be the result of cell fusion.

摘要

本文描述了两名患有大肠癌的患者，其肿瘤中发现了具有早熟染色体凝集（PCC）的细胞。肿瘤中PCC的百分比分别为6.9%和6.6%。我们推测，两名患者肿瘤细胞中存在的近四倍体染色体数可能是两个近二倍体恶性细胞融合的产物。此外，据推测，一些染色体数介于亚三倍体至亚四倍体水平之间的结直肠癌可能是细胞融合的结果。

相似文献

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Premature chromosome condensation in human large bowel cancer.人类大肠癌中的早熟染色体凝集
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