Wooding F B, Flint A P, Heap R B, Hobbs T
Cell Biol Int Rep. 1981 Aug;5(8):821-7. doi: 10.1016/0309-1651(81)90254-x.
The location of the fetomaternal junction in the placenta is important with respect to structural classification and the identification of any possible barrier to maternal immunorejection. Structural classification of the sheep placenta remains controversial on account of the uncertain origin of the syncytial layer. In this study [3H]thymidine was injected into the fetus and placentomes were removed between 4h and 21 days afterwards. Autoradiography showed that the syncytium is derived predominantly from the migration of fetal binucleate cells and not from the maternal uterine epithelium as most recent reports have suggested. In this respect the origin of the syncytium in the sheep placenta is similar to that reported in certain other eutherian mammals. The finding that cells originating from the fetal allograft survive after migration through the microvillous junction poses questions as to the mechanism by which the syncytial layer resists maternal immune rejection throughout gestation.
胎盘母胎交界处的位置对于结构分类以及识别母体免疫排斥的任何可能屏障而言都很重要。由于合胞体层起源不确定，绵羊胎盘的结构分类仍存在争议。在本研究中，将[³H]胸腺嘧啶核苷注入胎儿体内，随后在4小时至21天之间取出胎盘小叶。放射自显影显示，合胞体主要源自胎儿双核细胞的迁移，而非如最近的报告所表明的那样源自母体子宫上皮。在这方面，绵羊胎盘合胞体的起源与某些其他真兽类哺乳动物中所报道的起源相似。源自胎儿移植物的细胞在通过微绒毛交界处迁移后仍能存活，这一发现引发了关于合胞体层在整个妊娠期抵抗母体免疫排斥的机制的问题。
