Wooding F B, Hobbs T, Morgan G, Heap R B, Flint A P
AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, UK.
J Reprod Fertil. 1993 May;98(1):275-83. doi: 10.1530/jrf.0.0980275.
This paper demonstrates that in sheep and goats the two definitive fetomaternal interface layers are developmentally related. The fetal trophectoderm consists of binucleate and uninucleate cells. The apical microvilli of the trophectoderm interdigitate with a layer consisting of syncytial plaques of limited area bounding the maternal connective tissue. Our previous histological ultrastructural and immunocytochemical work has indicated that throughout pregnancy the fetal binucleate cells migrate to and fuse with the uterine epithelium or its derivatives to form these syncytial plaques which constitute a persistent fetomaternal tissue unique to ruminants. This quantitative autoradiographic study of thymidine incorporation into sheep and goat placentas confirms the central role of the binucleate cell in placental growth, demonstrates that throughout pregnancy all binucleate cells migrate and indicates that most of the nuclei of the syncytial plaques, which appear to have a limited lifespan, derive from binucleate cell fusion.
本文证明，在绵羊和山羊中，两个确定的母胎界面层在发育上是相关的。胎儿滋养外胚层由双核细胞和单核细胞组成。滋养外胚层的顶端微绒毛与一层由界定母体结缔组织的有限区域的合体斑块组成的层相互交错。我们之前的组织学、超微结构和免疫细胞化学研究表明，在整个妊娠期间，胎儿双核细胞迁移并与子宫上皮或其衍生物融合，形成这些合体斑块，这些斑块构成了反刍动物特有的持久母胎组织。这项对绵羊和山羊胎盘进行的胸腺嘧啶核苷掺入定量放射自显影研究证实了双核细胞在胎盘生长中的核心作用，表明在整个妊娠期间所有双核细胞都会迁移，并表明合体斑块中大多数似乎寿命有限的细胞核来自双核细胞融合。
