用放射免疫分析法研究二甲基亚硝胺给药后大鼠肝脏核仁DNA中O6-甲基鸟嘌呤的形成与修复。
The formation and repair of O6-methylguanine in rat liver nucleolar DNA after dimethylnitrosamine administration studied by radioimmunoassay.
作者信息
Kyrtopoulos S A, Vrotsou B
出版信息
Chem Biol Interact. 1981 Oct;37(1-2):191-7. doi: 10.1016/0009-2797(81)90176-9.
PMID:7285243
Abstract
The extent of formation and the rate of repair of O6-methylguanine in rat liver nucleolar DNA following administration of a single dose of dimethylnitrosamine have been studied by means of radioimmunoassay for O6-methyldeoxyguanosine. No difference has been found in either the extent of formation or the rate of repair of this lesion between nucleolar and whole nuclear DNA.
摘要
通过对O6 - 甲基脱氧鸟苷的放射免疫测定，研究了大鼠肝脏核仁DNA在单次给予二甲基亚硝胺后O6 - 甲基鸟嘌呤的形成程度和修复速率。在核仁DNA和整个核DNA之间，该损伤的形成程度或修复速率均未发现差异。
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