使用放射免疫分析法研究二甲基亚硝胺给药后小鼠肝脏卫星DNA和主带DNA中O6-甲基鸟嘌呤的形成与消失。
The use of radioimmunoassay to study the formation and disappearance of O6-methylguanine in mouse liver satellite and main-band DNA following dimethylnitrosamine administration.
作者信息
Kyrtopoulos S A, Swann P F
出版信息
J Cancer Res Clin Oncol. 1980;98(2):127-38. doi: 10.1007/BF00405957.
Abstract
A sensitive radioimmunoassay for O6-methyldeoxyguanosine has been developed, permitting the analysis of microgram amounts of DNA. This technique has been used in the study of the formation and removal of O6-methylguanine in mouse liver satellite and main-band DNA. The results indicate a reduced extent of O6-methylguanine formation in satellite DNA but similar rates of its removal from both classes of DNA.
摘要
已开发出一种用于检测O6-甲基脱氧鸟苷的灵敏放射免疫测定法，可用于分析微克量的DNA。该技术已用于研究小鼠肝脏卫星DNA和主带DNA中O6-甲基鸟嘌呤的形成和去除。结果表明，卫星DNA中O6-甲基鸟嘌呤的形成程度降低，但其从这两类DNA中去除的速率相似。
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