De Bevere V O, De Paepe M, De Leenheer A P, Nelis H J, Lambert W E, Claeys A E, Ringoir S
Clin Chim Acta. 1981 Aug 10;114(2-3):249-56. doi: 10.1016/0009-8981(81)90397-1.
Different high performance liquid chromatographic systems were applied to the investigation of vitamin A metabolism in subjects undergoing haemodialysis. Plasma levels of retinol, retinyl esters and retinoic acid were measured. There was a significant elevation of plasma retinol and dialysis failed to normalise this level. No correlation with plasma concentrations of creatinine or urea was found. No differences in retinyl ester and retinoic acid levels were observed between healthy subjects and haemodialysis patients. These results suggest that retinol accumulation is not caused by a deficiency in its oxidative metabolism.
采用不同的高效液相色谱系统研究接受血液透析患者的维生素A代谢情况。测定了血浆中视黄醇、视黄酯和视黄酸的水平。血浆视黄醇水平显著升高，血液透析未能使其恢复正常。未发现与血浆肌酐或尿素浓度存在相关性。在健康受试者和血液透析患者之间，未观察到视黄酯和视黄酸水平存在差异。这些结果表明，视黄醇的蓄积并非由其氧化代谢缺陷所致。
