高血压口服避孕药使用者体内乙炔雌二醇、咖啡因、醛固酮和脱氧皮质酮的血药浓度

Blood levels of ethynylestradiol, caffeine, aldosterone and desoxycorticosterone in hypertensive oral contraceptive users.

作者信息

Kaul L, Curry C L, Ahluwalia B S

出版信息

Contraception. 1981 Jun;23(6):643-51. doi: 10.1016/s0010-7824(81)80006-6.

Abstract

Twenty normotensive and ten hypertensive black women taking oral contraceptive (OC) were studied. Age, body weight, family medical history of hypertension, length of OC use, and type of OC were comparable. At midcycle approximately 10-12 hours following OC intake, blood was drawn and the plasma was used to determine ethynylestradiol (EE2), caffeine, aldosterone (Aldo) and desoxycorticosterone (DOC) levels. The results showed that in hypertensive OC users, EE2 and caffeine levels were significantly higher (P less than .01) compared to normotensive OC users. While no significant differences were found in Aldo and DOC levels between hypertensive and normotensive OC users, OC users had higher levels of Aldo (P less than .01) compared to non-OC users.

摘要

对20名血压正常和10名服用口服避孕药（OC）的高血压黑人女性进行了研究。年龄、体重、高血压家族病史、服用OC的时长和OC类型具有可比性。在月经周期中期，服用OC后约10 - 12小时采集血液，用血浆测定乙炔雌二醇（EE2）、咖啡因、醛固酮（Aldo）和脱氧皮质酮（DOC）水平。结果显示，与血压正常的OC使用者相比，高血压OC使用者的EE2和咖啡因水平显著更高（P小于0.01）。虽然高血压和血压正常的OC使用者之间的Aldo和DOC水平未发现显著差异，但与未服用OC的使用者相比，OC使用者的Aldo水平更高（P小于0.01）。