[Kinetics of cell proliferation in regenerating rat liver following subtotal resection].

Partial (78--80%) hepatectomy was conducted in male rats. The maximal mitotic activity of hepatocytes was seen 38--48 hours after the operation. It was found with thymidine-3H (pulse label) that the G2 period lasted 6 hours and the minimal duration of the S-period was 6 hours. During the liver regeneration after its subtotal resection there was asynchronization of the hepatocyte entrance into the S-period and mitosis, and cell retardation in the G1-and G2-periods. The mentioned changes in the hepatocyte proliferation are the results of intracellular metabolism disturbance under conditions of an excessive functional requirement.