[Effect of repeated partial hepatectomy on cell division in regenerating rat liver].

The repeated partial hepatectomy (PH) on day after a 70% PH induced the following effect on the passage of rat regenerating hepatocytes through the mitotic cycle: it delayed (for about 2 hours) the cells in the G2-period, it almost failed to change the duration of the S period and delayed (by 6 to 8 hours) the cells in the G1-period. The sham repeated operation induced an analogous effect. This indicated that the action of repeated PH on the mitotic cycle of regenerating hepatocytes was determined by the operation stress factor. An additional stimulation of division by the repeated PH influenced the regenerative process as a whole.