Val'dman A V, Shmidt Iu, Kozlovskaia M M, Andreas K, Fisher Kh
Farmakol Toksikol. 1981 May-Jun;44(3):270-5.
A pharmacological study was made on the basis of a comprehensive program aimed at collating the range of behavioral and neurochemical action of five compounds belonging to the thiaisochromane series. Compounds that possess an antidepressant action with a sedative component have been screened. It has been shown that the antidepressant effect to tisocromid applied clinically cannot be accounted for by the inhibiton of reverse monoamine uptake. The neurochemical profile of the test compounds appeared to differ from that of tricyclic antidepressants. These compounds did not inhibit the neuromediator uptake, exhibited no cholinolytic action, did not potentiate the peripheral effects of catecholamines.
基于一项全面计划进行了一项药理学研究，该计划旨在整理属于硫代异苯并二氢吡喃系列的五种化合物的行为和神经化学作用范围。已筛选出具有抗抑郁作用并带有镇静成分的化合物。结果表明，临床上应用的替索罗米的抗抑郁作用不能用抑制单胺逆向摄取来解释。受试化合物的神经化学特征似乎与三环类抗抑郁药不同。这些化合物不抑制神经递质摄取，不表现出抗胆碱作用，不增强儿茶酚胺的外周效应。
