Scott J R, Keye W R, Poulson A M, Reynolds W A
Fertil Steril. 1981 Oct;36(4):512-5. doi: 10.1016/s0015-0282(16)45803-6.
We have developed a technique for orthotopic transplantation of ovaries by microsurgical reanastomosis of the ovarian blood vessels in rhesus monkeys. Four monkeys receiving autografts resumed cyclic menses and had postoperative circulating luteinizing hormone (LH) and progesterone concentrations consistent with developing follicles and corpus luteum function. Postoperative luteal phase ovarian biopsies were indicative of ovulation in three of the four animals. However, in a fifth recipient an ovarian allograft from an unrelated donor was rejected despite the use of a standard immunosuppressive regimen. This study suggests that ovarian transplantation by direct vascular anastomosis is a technically feasible surgical procedure in the human, where the vascular anatomy is similar and the caliber of the ovarian vessels if greater than in the rhesus monkey.
我们已经开发出一种通过恒河猴卵巢血管显微外科再吻合进行卵巢原位移植的技术。四只接受自体移植的猴子恢复了周期性月经，术后循环中的促黄体生成素（LH）和孕酮浓度与卵泡发育和黄体功能一致。四只动物中有三只术后黄体期卵巢活检表明有排卵。然而，在第五只接受者中，尽管使用了标准免疫抑制方案，但来自无关供体的卵巢同种异体移植仍被排斥。这项研究表明，直接血管吻合的卵巢移植在人类中是一种技术上可行的外科手术，因为人类的血管解剖结构相似，且卵巢血管的管径比恒河猴的大。
