Gourley G R, Chesney P J, Davis J P, Odell G B
Gastroenterology. 1981 Nov;81(5):928-31.
Serum liver function tests were performed in 22 females fulfilling the criteria for toxic-shock syndrome. All patients showed evidence of hepatic dysfunction during their hospital course. These findings included hyperbilirubinemia in the absence of laboratory evidence for significant hemolysis, mold elevation of the transaminases, threefold increase in their serum bile salt concentration, and hypoalbuminemia. These findings are best explained by hypoperfusion of the liver and a canalicular injury secondary to staphylococcal exotoxin. Cholestasis appears to be a universal finding in toxic-shock syndrome.
对22名符合中毒性休克综合征标准的女性进行了血清肝功能检查。所有患者在住院期间均表现出肝功能障碍的迹象。这些表现包括无明显溶血实验室证据情况下的高胆红素血症、转氨酶的适度升高、血清胆汁盐浓度增加三倍以及低白蛋白血症。这些表现最好的解释是肝脏灌注不足以及葡萄球菌外毒素继发的胆小管损伤。胆汁淤积似乎是中毒性休克综合征的普遍表现。
