Ohkubo H, Okuda K, Iida S
Hepatology. 1981 Jul-Aug;1(4):319-24. doi: 10.1002/hep.1840010407.
The kinetics of plasma clearance of indocyanine green and bromosulfophthalein were studied in 49 consecutive patients with chronic unconjugated hyperbilirubinemia. Forty-four patients had Gilbert's syndrome whereas five patients had impaired hepatic uptake of indocyanine green and virtually normal hepatic bromosulfophthalein uptake. There was no difference in bilirubin metabolism between the two groups. A family study of the patients with impaired indocyanine green uptake revealed that the defect appears to be transmitted as an autosomal dominant trait associated with inheritance of impaired bilirubin metabolism. These patients manifest a noval disorder of organic anion transport which, like Gilbert's syndrome, is also characterized by chronic milk unconjugated hyperbilirubinemia.
对49例连续性慢性非结合胆红素血症患者进行了吲哚菁绿和溴磺酞钠血浆清除动力学研究。44例患者患有吉尔伯特综合征，而5例患者吲哚菁绿肝脏摄取受损，肝脏溴磺酞钠摄取基本正常。两组之间胆红素代谢无差异。对吲哚菁绿摄取受损患者的家族研究显示，该缺陷似乎作为常染色体显性性状传递，与胆红素代谢受损的遗传相关。这些患者表现出一种新的有机阴离子转运障碍，与吉尔伯特综合征一样，其特征也是慢性轻度非结合胆红素血症。
