Whittaker M, Britten J J
Hum Hered. 1981;31(4):242-7. doi: 10.1159/000153216.
A steroid, the dibutyrate analogue of pancuronium bromide (9.8 X 10(-8)M), has been used as differential inhibitor in the study of the plasma cholinesterase variants. Pancuronium dibutyrate numbers have been measured for 190 individuals, and the mean values for six of the known genotypes, E1uE1u, E1uE1f, E1uE1a, E1fE1a, E1aE1a, and E1fE1f, have been calculated. Evidence is presented that a combination of the pancuronium dibutyrate number and the fluoride number give better resolution of the six genotypes than the combination of the pancuronium dibutyrate and the dibucaine number. This new differential inhibitor has real potential for revealing the probable existence of new genotypes.
一种类固醇，即溴化潘库溴铵的二丁酸类似物（9.8×10⁻⁸M），已被用作研究血浆胆碱酯酶变体的差异抑制剂。已对190名个体测定了二丁酸潘库溴铵数值，并计算了六种已知基因型E1uE1u、E1uE1f、E1uE1a、E1fE1a、E1aE1a和E1fE1f的平均值。有证据表明，与二丁酸潘库溴铵和丁卡因数值的组合相比，二丁酸潘库溴铵数值与氟化物数值的组合能更好地分辨这六种基因型。这种新型差异抑制剂在揭示可能存在的新基因型方面具有实际潜力。
