维库溴铵和泮库溴铵对人呼吸道胆碱酯酶的抑制作用。

Cholinesterase inhibition by vecuronium and pancuronium in human airways.

作者信息

Norel X, Labat C, De Santis D, Gorenne I, Dulmet E, Rossi F, Brink C

机构信息

CNRS URA 1159, Centre Chirurgical Marie-Lannelongue, Le Plessis-Robinson, France.

出版信息

Life Sci. 1994;55(14):PL261-6. doi: 10.1016/0024-3205(94)00248-7.

DOI:10.1016/0024-3205(94)00248-7

PMID:7916437

Abstract

Vecuronium (100 microM) but not pancuronium (100 microM) increased the sensitivity of human isolated bronchial preparations (HBP) to exogenous acetylcholine (ACh). The pD2 values obtained from concentration-dependent contractions were: control, 4.59 +/- 0.29 vecuronium, 5.86 +/- 0.31. Vecuronium or pancuronium (100 microM) significantly decreased (50%) the neostigmine contractions in HBP. In addition, vecuronium was more potent than pancuronium in preventing exogenous ACh degradation. These results suggest that vecuronium and pancuronium may have physiological effects in human airways by inhibiting both the tissue cholinesterases and muscarinic (M3) receptors.

摘要

维库溴铵（100微摩尔）而非泮库溴铵（100微摩尔）可增加人离体支气管制剂（HBP）对外源性乙酰胆碱（ACh）的敏感性。从浓度依赖性收缩获得的pD2值为：对照组，4.59±0.29；维库溴铵组，5.86±0.31。维库溴铵或泮库溴铵（100微摩尔）可使HBP中新斯的明收缩显著降低（50%）。此外，在防止外源性ACh降解方面，维库溴铵比泮库溴铵更有效。这些结果表明，维库溴铵和泮库溴铵可能通过抑制组织胆碱酯酶和毒蕈碱（M3）受体而在人体气道中产生生理效应。