绿曼巴蛇（Dendroaspis angusticeps）全毒液对骨骼、神经肌肉和平滑肌的作用 - I

Skeletal neuromuscular and smooth muscle effects of whole venom of the green mamba, Dendroaspis angusticeps - I.

作者信息

Wangai J, Thairu K, Telang B V

出版信息

Indian J Physiol Pharmacol. 1981 Apr-Jun;25(2):176-9.

Abstract

Dendroaspis angusticeps venom (75 micrograms/ml) caused an irreversible blockade of the directly as well as directly evoked contractions of the rat hemidiaphragm and indirectly evoked contractions of the chick biventer cervicis muscle. The venom itself also produced a contraction of the frog rectus abdominis muscle, rat fundal strip, rat uterus and nictitating membrane of the cat; however, it did alter responses of nictitating membrane to preganglionic electrical stimulation and to ganglion stimulant drugs. The effect was attributed to the presence of acetylcholine-like substance in the venom.

摘要

绿曼巴蛇毒液（75微克/毫升）可导致大鼠半膈肌直接和间接诱发的收缩以及鸡双颈肌间接诱发的收缩出现不可逆的阻滞。毒液本身也可引起青蛙腹直肌、大鼠胃底条、大鼠子宫和猫瞬膜的收缩；然而，它确实改变了瞬膜对节前电刺激和神经节兴奋药物的反应。这种作用归因于毒液中存在类乙酰胆碱物质。