孕期禁食对营养良好和营养不良大鼠的母体及胎儿体重与身体成分的影响。

Effects of fasting during pregnancy on maternal and fetal weight and body composition in well-nourished and undernourished rats.

作者信息

Lederman S A, Rosso P

出版信息

J Nutr. 1981 Oct;111(10):1823-32. doi: 10.1093/jn/111.10.1823.

DOI:10.1093/jn/111.10.1823

Abstract

The effect of a 2-day fast on fetal and maternal weight and composition was determined in ad libitum-fed and food-restricted pregnant and non-pregnant rats. Fasting between days 17 and 19 of gestation resulted in a greater loss of net maternal body weight in ad libitum-fed pregnant than in nonpregnant rats, and also a greater loss of body fat. In contrast, food-restricted pregnant rats, also fasted from day 17 to day 19 of gestation, maintained their net body weight and body fat during the fast as did nonpregnant rats fasted for the same length of time. Fetal weight was not significantly reduced by fasting in the ad libitum-fed rats but was reduced by 25% in the previously food-restricted rats. The results demonstrate that prior maternal nutritional status strongly influences the effects of fasting on the fetus and that maternal nutrient stores are not mobilized for fetal utilization even when fetal growth is markedly impaired.

摘要

在随意进食和食物受限的怀孕及未怀孕大鼠中，测定了为期2天的禁食对胎儿和母体体重及组成的影响。在妊娠第17天至19天期间禁食，与未怀孕大鼠相比，随意进食的怀孕大鼠母体净体重损失更大，体脂损失也更大。相比之下，同样在妊娠第17天至19天禁食的食物受限怀孕大鼠，在禁食期间保持了净体重和体脂，与禁食相同时长的未怀孕大鼠情况相同。在随意进食的大鼠中，禁食并未显著降低胎儿体重，但在先前食物受限的大鼠中，胎儿体重降低了25%。结果表明，母体先前的营养状况强烈影响禁食对胎儿的作用，并且即使胎儿生长明显受损，母体营养储备也不会被调动以供胎儿利用。