Lederman S A, Rosso P
J Nutr. 1981 Dec;111(12):2162-71. doi: 10.1093/jn/111.12.2162.
The effects of obesity and food restriction on fetal and maternal body weight and on maternal body composition were determined in pregnant and nonpregnant rats. Obesity was induced by several weeks of ad libitum feeding of a varied diet of retail food products which continued until experimental day 5 (gestational age in pregnant groups). From day 5 all groups were fed a standard diet. Ad libitum-fed obese pregnant rats gained less weight during pregnancy than non-obese rats. All rats which were 60% food restricted lost body weight. Weight loss in obese rats was due to loss of body fat whereas non-obese rats lost lean tissue as well. Obese pregnant rats ended the food restriction period 62 g heavier than non-obese restricted pregnant rats and had the same carcass weight and composition as ad libitum fed non-obese nonpregnant rats. Fetal and placental weight was reduced 25 percent by food restriction in obese as well as non-obese groups. These results indicate that during food restriction the fetal rat cannot parasitize maternal nutrient stores to prevent growth retardation, even if the mother is obese.
在怀孕和未怀孕的大鼠中，研究了肥胖和食物限制对胎儿及母体体重以及母体身体组成的影响。通过连续数周随意喂食各种零售食品来诱导肥胖，这种饮食方式持续到实验第5天（怀孕组的妊娠年龄）。从第5天起，所有组均喂食标准饮食。随意喂食的肥胖怀孕大鼠在孕期体重增加比非肥胖大鼠少。所有食物摄入量受限60%的大鼠体重均减轻。肥胖大鼠体重减轻是由于体脂减少，而非肥胖大鼠除了体脂减少外，瘦组织也减少。肥胖怀孕大鼠在食物限制期结束时比非肥胖限制怀孕大鼠重62克，其胴体重量和组成与随意喂食的非肥胖未怀孕大鼠相同。肥胖组和非肥胖组中，食物限制均使胎儿和胎盘重量减少了25%。这些结果表明，在食物限制期间，即使母亲肥胖，胎鼠也无法利用母体营养储备来防止生长迟缓。
