Ikeda I, Kawasaki A, Samezima K, Sugano M
J Nutr Sci Vitaminol (Tokyo). 1981;27(3):243-51. doi: 10.3177/jnsv.27.243.
The antihypercholesterolemic activity of beta-sitosterol and beta-sitostanol was compared in male rabbits given a cholesterol-supplemented diet. beta-Sitosterol and beta-sitostanol were fed to these rabbits at the 0.5% level with cholesterol (0.5% and 0.2% in experiments I and II, respectively). The serum cholesterol level tended to be lower in rabbits fed beta-sitostanol than in the animals fed beta-sitosterol even in experiment I. The beta-sitostanol exhibited a significantly greater hypocholesterolemic activity in experiment II, LDL-cholesterol being decreased markedly. The liver cholesterol decreased in both groups of rabbits to a similar extent. beta-Sitostanol prevented more effectively the formation of dietary cholesterol-induced atheroma in the abdominal aorta than beta-sitosterol. It is most likely, together with the data reported previously on rats, that the hypocholesterolemic activity of beta-sitostanol results from the significantly greater inhibitory effect on the intestinal absorption of cholesterol than that of beta-sitosterol.
在给予补充胆固醇饮食的雄性兔子中，比较了β-谷甾醇和β-谷甾烷醇的抗高胆固醇活性。以0.5%的水平将β-谷甾醇和β-谷甾烷醇与胆固醇一起喂给这些兔子（在实验I和II中，胆固醇含量分别为0.5%和0.2%）。即使在实验I中，喂食β-谷甾烷醇的兔子血清胆固醇水平也往往低于喂食β-谷甾醇的动物。在实验II中，β-谷甾烷醇表现出显著更强的降胆固醇活性，低密度脂蛋白胆固醇明显降低。两组兔子的肝脏胆固醇均下降到相似程度。与β-谷甾醇相比，β-谷甾烷醇更有效地预防了饮食胆固醇诱导的腹主动脉粥样硬化形成。与先前关于大鼠的报道数据一起，很可能β-谷甾烷醇的降胆固醇活性源于其对胆固醇肠道吸收的抑制作用明显强于β-谷甾醇。
