Mouse midbrain tryptophan hydroxylase: strain differences in variational properties.

Biochemical studies of kinetic conformations and assessment of statistical patterns of variation around mean velocity slopes were used to characterize midbrain tryptophan hydroxylase (TPOH) from two behaviorally different mouse strains, C57B1/6J and A/J. The data suggest that the two strains manifest forms of TPOH with different stabilities and regulatory properties.