2-（2-呋喃基）-3-（5-硝基-2-呋喃基）丙烯酰胺对冷冻保存的叙利亚金仓鼠原代细胞的恶性转化作用
Malignant transformation of cryopreserved early passage syrian golden hamster cells by 2-(2-furyl)-3-(5-nitro-2-furyl)-acrylamide.
作者信息
Pienta R J, Lebherz W B, Takayama S
出版信息
Cancer Lett. 1978 Nov;5(5):245-51. doi: 10.1016/s0304-3835(78)80021-4.
PMID:728882
Abstract
2-(2-Furyl)-3-(5-nitro-2-furyl)-acrylamide (AF-2) induced the malignant transformation of secondary cultures of Syrian golden hamster embryo cells prepared from cryopreserved primary cells. Transformed cells grew in semi-solid agar medium and formed sarcomas when inoculated subcutaneously into non-immunosuppressed suckling hamsters.
摘要
2-（2-呋喃基）-3-（5-硝基-2-呋喃基）丙烯酰胺（AF-2）可诱导由冷冻保存的原代细胞制备的叙利亚金黄地鼠胚胎细胞二次培养物发生恶性转化。转化细胞能在半固体琼脂培养基中生长，当皮下接种到未免疫抑制的乳仓鼠体内时会形成肉瘤。
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