[Effect of ischemic heart disease risk factors on plasma and vascular-thrombocyte hemostasis].

In 222 men aged 40-59 with ischaemic heart disease an epidemiological investigation established the influence of risk factors (hypercholesterolaemia, hypertension, overweight and smoking) on the vasculo-thrombocytic haemostasis. It was found that the similarity of action of risk factors in increased with their combinations. The authors found enhancement of the contact activity of the blood, the sensitivity of the thrombocytes to aggregants, the reaction of isolation of platelets, the content of the pathological forms of fibrin and fibrinogen, the acceleration of coagulation and the slowing down of retraction. These shifts are considered as an activation of the coagulation system in circulation.